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Re: “Does Arsenic Exposure Increase the Risk for Circulatory Disease?” – The Authors Reply


Hertz-Picciotto, Irva; Hu, Suh-Woan; & Arrighi, H. Michael (2000). Re: "Does Arsenic Exposure Increase the Risk for Circulatory Disease?" - The Authors Reply. American Journal of Epidemiology, 152(3), 293.


In response to our recent paper (1) suggesting an association between circulatory disease mortality and occupational arsenic exposure that is seen only after adjustment for the healthy worker survivor effect, Lubin and Fraumeni (2) have reanalyzed data from the Anaconda smelter worker cohort. They are in agreement that there is biologic plausibility to this association, based largely on studies in populations with ingestion exposure, and despite their finding of no significant trend between duration of exposure and circulatory disease mortality, they and we believe that the data to date are not conclusive.


Reference Type

Journal Article

Year Published


Journal Title

American Journal of Epidemiology


Hertz-Picciotto, Irva
Hu, Suh-Woan
Arrighi, H. Michael