CitationBrown, Charlotte A.; McKinney, Kimberly Q.; Kaufman, Jay S.; Gravel, Roy A.; & Rozen, Rima (2000). A Common Polymorphism in Methionine Synthase Reductase Increases Risk of Premature Coronary Artery Disease. Journal of Cardiovascular Risk, 7(3), 197-200.
AbstractBackground: Methionine synthase reductase (MTRR) catalyzes the regeneration of methylcobalamin, a cofactor of methionine synthase, an enzyme essential for maintaining adequate intracellular pools of methionine and tetrahydrofolate, as well as for maintaining homocysteine concentrations at nontoxic levels. We recently identified a common A-->G polymorphism at position 66 of the cDNA sequence of MTRR; this variant was associated with a greater than normal risk for spina bifida in the presence of low levels of cobalamin.
Reference TypeJournal Article
Journal TitleJournal of Cardiovascular Risk
Author(s)Brown, Charlotte A.
McKinney, Kimberly Q.
Kaufman, Jay S.
Gravel, Roy A.