Menu Close

A Common Polymorphism in Methionine Synthase Reductase Increases Risk of Premature Coronary Artery Disease

Citation

Brown, Charlotte A.; McKinney, Kimberly Q.; Kaufman, Jay S.; Gravel, Roy A.; & Rozen, Rima (2000). A Common Polymorphism in Methionine Synthase Reductase Increases Risk of Premature Coronary Artery Disease. Journal of Cardiovascular Risk, 7(3), 197-200.

Abstract

Background: Methionine synthase reductase (MTRR) catalyzes the regeneration of methylcobalamin, a cofactor of methionine synthase, an enzyme essential for maintaining adequate intracellular pools of methionine and tetrahydrofolate, as well as for maintaining homocysteine concentrations at nontoxic levels. We recently identified a common A-->G polymorphism at position 66 of the cDNA sequence of MTRR; this variant was associated with a greater than normal risk for spina bifida in the presence of low levels of cobalamin.

URL

http://dx.doi.org/10.1177/204748730000700306

Reference Type

Journal Article

Journal Title

Journal of Cardiovascular Risk

Author(s)

Brown, Charlotte A.
McKinney, Kimberly Q.
Kaufman, Jay S.
Gravel, Roy A.
Rozen, Rima

Year Published

2000

Volume Number

7

Issue Number

3

Pages

197-200

Reference ID

1607