Citation
Hall, Amber M.; Keil, Alexander P.; Choi, Giehae; Ramos, Amanda M.; Richardson, David B.; Olshan, Andrew F.; Martin, Chantel L.; Villanger, Gro D.; Reichborn-Kjennerud, Ted; & Zeiner, Pål, et al. (2023). Prenatal Organophosphate Ester Exposure and Executive Function in Norwegian Preschoolers. Environmental Epidemiology, 7(3), e251. PMCID: PMC10256412Abstract
Organophosphate esters (OPEs) are ubiquitous chemicals, used as flame retardants and plasticizers. OPE usage has increased over time as a substitute for other controlled compounds. This study investigates the impact of prenatal OPE exposure on executive function (EF) in preschoolers.METHODS: We selected 340 preschoolers from the Norwegian Mother, Father, and Child Cohort Study. Diphenyl-phosphate (DPhP), di-n-butyl-phosphate (DnBP), bis(2-butoxyethyl) phosphate (BBOEP), and bis(1,3-dichloro-2-propyl) phosphate (BDCIPP) were measured in maternal urine. EF was measured using the Behavior Rating Inventory of Executive Functioning-Preschool (BRIEF-P) and the Stanford-Binet fifth edition (SB-5). EF scores were scaled so a higher score indicated worse performance. We estimated exposure-outcome associations and evaluated modification by child sex using linear regression.
RESULTS: Higher DnBP was associated with lower EF scores across multiple rater-based domains. Higher DPhP and BDCIPP were associated with lower SB-5 verbal working memory (
URL
http://dx.doi.org/10.1097/ee9.0000000000000251Reference Type
Journal ArticleYear Published
2023Journal Title
Environmental EpidemiologyAuthor(s)
Hall, Amber M.Keil, Alexander P.
Choi, Giehae
Ramos, Amanda M.
Richardson, David B.
Olshan, Andrew F.
Martin, Chantel L.
Villanger, Gro D.
Reichborn-Kjennerud, Ted
Zeiner, Pål
Øvergaard, Kristin R.
Sakhi, Amrit K.
Thomsen, Cathrine
Aase, Heidi
Engel, Stephanie M.
Article Type
RegularPMCID
PMC10256412Data Set/Study
Norwegian Mother, Father, and Child Cohort Study (MoBa)Continent/Country
NorwayORCiD
Olshan - 0000-0001-9115-5128Martin, C. - 0000-0003-1907-0810