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Grasch, Jennifer L.; de Voest, Jessica A.; Saade, George R.; Hughes, Brenna L.; Reddy, Uma M.; Costantine, Maged M.; Chien, Edward K.; Tita, Alan T. N.; Thorp, John M., Jr.; & Metz, Torri D., et al. (Online ahead of print). Breastfeeding Initiation, Duration, and Associated Factors among People with Hepatitis C Virus Infection. Obstetrics & Gynecology.


OBJECTIVE: To characterize breastfeeding behaviors and identify factors associated with breastfeeding initiation among people with hepatitis C virus (HCV) infection.
METHODS: We conducted a secondary analysis of a multicenter observational cohort of pregnant people with singleton gestations and HCV seropositivity. This analysis includes individuals with data on breastfeeding initiation and excludes those with human immunodeficiency virus (HIV) co-infection. The primary outcome was self-reported initiation of breastfeeding or provision of expressed breast milk. Secondary outcomes included duration of breastfeeding. Demographic and obstetric characteristics were compared between those who initiated breastfeeding and those who did not to identify associated factors. Univariable and multivariable analyses were performed.
RESULTS: Overall, 579 individuals (75.0% of participants in the parent study) were included. Of those, 362 (62.5%) initiated breastfeeding or provided breast milk to their infants, with a median duration of breastfeeding of 1.4 months (interquartile range 0.5-6.0). People with HCV viremia, defined as a detectable viral load at any point during pregnancy, were less likely to initiate breastfeeding than those who had an undetectable viral load (59.4 vs 71.9%, adjusted odds ratio [aOR] 0.61, 95% CI, 0.41-0.92). People with private insurance were more likely to initiate breastfeeding compared with those with public insurance or no insurance (80.0 vs 60.1%; aOR 2.43, 95% CI, 1.31-4.50).
CONCLUSION: Although HCV seropositivity is not a contraindication to breastfeeding regardless of viral load, rates of breastfeeding initiation were lower among people with HCV viremia than among those with an undetectable viral load.


Reference Type

Journal Article

Year Published

Online ahead of print

Journal Title

Obstetrics & Gynecology


Grasch, Jennifer L.
de Voest, Jessica A.
Saade, George R.
Hughes, Brenna L.
Reddy, Uma M.
Costantine, Maged M.
Chien, Edward K.
Tita, Alan T. N.
Thorp, John M., Jr.
Metz, Torri D.
Wapner, Ronald J.
Sabharwal, Vishakha
Simhan, Hyagriv N.
Swamy, Geeta K.
Heyborne, Kent D.
Sibai, Baha M.
Grobman, William A.
El-Sayed, Yasser Y.
Casey, Brian M.
Parry, Samuel, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network

Article Type


Data Set/Study

An Observational Study of Hepatitis C in Pregnancy


United States




Thorp - 0000-0002-9307-6690