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Breast-Feeding and Neuroblastoma, USA and Canada


Daniels, Julie L.; Olshan, Andrew F.; Pollock, Brad H.; Shah, Narayan R.; & Stram, Daniel O. (2002). Breast-Feeding and Neuroblastoma, USA and Canada. Cancer Causes & Control, 13(5), 401-405.


Objective: Researchers have suggested an inverse association between breast-feeding and risk of childhood cancer. We investigated the association between breast-feeding and neuroblastoma in a large case–control study in the United States and Canada.
Methods: Maternal reports of breast-feeding were compared among 393 children six months or older who had neuroblastoma and were identified through the Children's Cancer Group and the Pediatric Oncology Group and 376 age-matched controls identified by random-digit telephone dialing in a telephone interview case–control study.
Results: Children with neuroblastoma were less likely to have breast-fed than control children (odds ratio (OR) = 0.6; 95% confidence interval (CI) = 0.5–0.9). The association between breast-feeding and neuroblastoma increased with breast-feeding duration (0–3 months OR = 0.7, CI = 0.4–1.0; 13+ months OR = 0.5, CI = 0.3–0.9).
Conclusion: Breast-feeding was inversely associated with neuroblastoma and should be encouraged among healthy mothers. Additional research on possible mechanisms of this association may be warranted.


Reference Type

Journal Article

Year Published


Journal Title

Cancer Causes & Control


Daniels, Julie L.
Olshan, Andrew F.
Pollock, Brad H.
Shah, Narayan R.
Stram, Daniel O.