Menu Close

Central Hemodynamic Effects of an Oxytocin Receptor Antagonist (Atosiban) in the Isolated, Perfused Rat Heart

Citation

Thorp, John M., Jr.; Mayer, David C.; & Kuller, Jeffrey A. (1999). Central Hemodynamic Effects of an Oxytocin Receptor Antagonist (Atosiban) in the Isolated, Perfused Rat Heart. Journal of the Society for Gynecologic Investigation, 6(4), 186-7.

Abstract

Objective: Atosiban is a selective oxytocin receptor antagonist capable of inhibiting oxytocin-induced contractility of the uterus. Trials of this agent in intact animals and women as a tocolytic agent for preterm labor have shown atosiban to be devoid of cardiac effects. This is in contrast to other tocolytic agents, which have profound hemodynamic effects. We conducted this study to determine the cardiac effect of atosiban in the isolated, perfused rat heart model.

URL

http://dx.doi.org/

Reference Type

Journal Article

Journal Title

Journal of the Society for Gynecologic Investigation

Author(s)

Thorp, John M., Jr.
Mayer, David C.
Kuller, Jeffrey A.

Year Published

1999

Volume Number

6

Issue Number

4

Pages

186-7

Reference ID

2586