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Second Trimester Folate Status and Preterm Birth

Citation

Siega-Riz, Anna Maria; Savitz, David A; .; Zeisel, Steven H.; Thorp, John M., Jr.; & Herring, Amy H. (2004). Second Trimester Folate Status and Preterm Birth. American Journal of Obstetrics & Gynecology, 191(6), 1851-1857.

Abstract

OBJECTIVE: The purpose of this study was to show that maternal folate status during pregnancy may be related to preterm birth.
STUDY DESIGN: Women were recruited at 24 to 29 weeks' gestation from 1995 to 2000 into the Pregnancy, Infection, and Nutrition Study. Those who completed an interview and a food frequency questionnaire, or provided a blood sample for radioassay of serum (n = 2026) and red blood cell (n = 1034) folate were included.
RESULTS: Mean daily dietary folate intake was 463 microg (SD +/- 248). Intake CONCLUSION: These results support the hypothesis that low folate levels during the second trimester of pregnancy are associated with an increased risk of preterm birth.

URL

http://dx.doi.org/10.1016/j.ajog.2004.07.076

Reference Type

Journal Article

Year Published

2004

Journal Title

American Journal of Obstetrics & Gynecology

Author(s)

Siega-Riz, Anna Maria
Savitz, David A
.
Zeisel, Steven H.
Thorp, John M., Jr.
Herring, Amy H.