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Second Trimester Folate Status and Preterm Birth


Siega-Riz, Anna Maria; Savitz, David A; .; Zeisel, Steven H.; Thorp, John M., Jr.; & Herring, Amy H. (2004). Second Trimester Folate Status and Preterm Birth. American Journal of Obstetrics & Gynecology, 191(6), 1851-1857.


OBJECTIVE: The purpose of this study was to show that maternal folate status during pregnancy may be related to preterm birth.
STUDY DESIGN: Women were recruited at 24 to 29 weeks' gestation from 1995 to 2000 into the Pregnancy, Infection, and Nutrition Study. Those who completed an interview and a food frequency questionnaire, or provided a blood sample for radioassay of serum (n = 2026) and red blood cell (n = 1034) folate were included.
RESULTS: Mean daily dietary folate intake was 463 microg (SD +/- 248). Intake CONCLUSION: These results support the hypothesis that low folate levels during the second trimester of pregnancy are associated with an increased risk of preterm birth.


Reference Type

Journal Article

Year Published


Journal Title

American Journal of Obstetrics & Gynecology


Siega-Riz, Anna Maria
Savitz, David A
Zeisel, Steven H.
Thorp, John M., Jr.
Herring, Amy H.