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Klonoff-Cohen, Hillary; Edelstein, Sharon; & Savitz, David A. (1993). Cigarette Smoking and Preeclampsia. Obstetrics & Gynecology, 81(4), 541-544.


Objective: To examine the relationship between cigarette smoking during pregnancy and the development of preeclampsia.
Methods: A case-control study compared the smoking histories of 110 nulliparous preeclamptic women and 115 healthy nulliparas aged 15-35 years who delivered at North Carolina Memorial Hospital.
Results: Unconditional logistic regression relating smoking during pregnancy to preeclampsia yielded an odds ratio of 0.71 (95% confidence interval 0.33-1.50) when adjusting for working during pregnancy, alcohol use, medication use, contraceptive choices with the father of the index pregnancy, and family history of preeclampsia. There was no evidence of a dose-response effect of reduced risk for heavier smokers.
Conclusions: Despite major methodologic improvements from previous studies, including rigorous diagnostic criteria for preeclampsia, a negative, non-statistically significant association persisted between cigarette smoking during pregnancy and preeclampsia, similar in magnitude to that of previous reports.


Reference Type

Journal Article

Year Published


Journal Title

Obstetrics & Gynecology


Klonoff-Cohen, Hillary
Edelstein, Sharon
Savitz, David A.