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Descriptive Evidence That Risk Profiles for Cervical Intraepithelial Neoplasia 1, 2, and 3 Are Unique


Belinson, Suzanne; Smith, Jennifer S.; Myers, Evan; Olshan, Andrew F.; Belinson, Jerome; Pretorius, Robert; Qiao, You-lin; & Hartmann, Katherine E. (2008). Descriptive Evidence That Risk Profiles for Cervical Intraepithelial Neoplasia 1, 2, and 3 Are Unique. Cancer Epidemiology, Biomarkers & Prevention, 17(9), 2350-2355.


OBJECTIVE: This study aimed to estimate if risk factor profiles for histologically confirmed cervical intraepithelial neoplasia (CIN) 2 lesions differ from those for CIN 1 or 3.
METHODS: A total of 2,055 women positive for high-risk human papillomavirus, with a minimum of five cervical biopsies, were enrolled in the Shanxi Province Cervical Cancer Screening Study II. We evaluated risk factor profiles for CIN 2 in comparison with CIN 1 and 3. Polytomous logistic regression was used to generate odds ratios and corresponding 95% confidence intervals and to test for differences in odds ratios across histologic grades.
RESULTS: The risk for CIN 3 associated with three or more pregnancies and sexual intercourse within 4 months of childbirth was higher than that for CIN 2 (P(difference) = 0.02 and 0.0007, respectively). Significant differences in the associations of age groups with CIN 1 and 2 were observed, such that there were positive associations with CIN 2 but none for CIN 1. There was no difference in the association of number of sexual partners or reported number of abortions between CIN 1 and 2 or between CIN 3 and 2.
CONCLUSIONS: In our study, the patterns of risk factor profiles for CIN 1, 2, and 3 were unique. Conventional grouping of CIN 2 with 3 for analysis of risk factors may need revisiting. (Cancer Epidemiol Biomarkers Prev 2008;17(9):2350-5).


Reference Type

Journal Article

Year Published


Journal Title

Cancer Epidemiology, Biomarkers & Prevention


Belinson, Suzanne
Smith, Jennifer S.
Myers, Evan
Olshan, Andrew F.
Belinson, Jerome
Pretorius, Robert
Qiao, You-lin
Hartmann, Katherine E.