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Ethical Challenges in Efficacy Trials of Vaginal Microbicides for HIV Prevention

Citation

de Zoysa, Isabelle; Elias, Christopher J.; & Bentley, Margaret E. (1998). Ethical Challenges in Efficacy Trials of Vaginal Microbicides for HIV Prevention. American Journal of Public Health, 88(4), 571-5. PMCID: PMC1508426

Abstract

This paper discusses some of the ethical challenges raised by advanced clinical trials designed to assess the safety and efficacy of vaginal microbicides in protecting women from HIV infection. The ethical principles that guide clinical research involving human subjects require that all participants in such trials be provided available measures known to reduce the risk of HIV infection. However, this will reduce the ability of the study to assess the protective effect of the test microbicide. In addition, providing extensive services to trial participants may be construed as an undue inducement if the study is being conducted among vulnerable groups such as sex workers or women from disadvantaged communities. Suggestions are provided to resolve this dilemma in the planning and implementation of HIV prevention services for trial participants.

URL

http://dx.doi.org/10.2105/ajph.88.4.571

Notes

ProCite field[28]: PMC1508426

Reference Type

Journal Article

Journal Title

American Journal of Public Health

Author(s)

de Zoysa, Isabelle
Elias, Christopher J.
Bentley, Margaret E.

Year Published

1998

Volume Number

88

Issue Number

4

Pages

571-5

PMCID

PMC1508426

Reference ID

3531