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Genetic Implications of Mating Structure in a Caribbean Isolate

Citation

Leslie, Paul W.; Morrill, Warren T.; & Dyke, Bennett (1981). Genetic Implications of Mating Structure in a Caribbean Isolate. American Journal of Human Genetics, 33(1), 90-104. PMCID: PMC1684887

Abstract

Mating patterns in the population of St. Barthélémy, French West Indies, are examined to evaluate the expected genetic consequences of consanguinity avoidance and of failure to mate due to celibacy and emigration. Nearly 60% of all individuals reaching mating age on "St. Bart" never contribute to the gene pool of succeeding generations. This greatly reduces the effective population size and, therefore, increases genetic drift or random inbreeding. The consequent loss of heterozygosity is partially countered by the fact that the individuals who fail to reproduce within the population tend to be more closely related to the population than are those who do reproduce. This nonrandom failure to mate results in nonrandom inbreeding, which reduces total pedigree inbreeding. Total inbreeding is also reduced by consanguinity avoidance. However, the effect of avoiding close consanguineous matings is, to some extent, reversed by an apparent preference for more distant relationships, especially with second cousins. Generally similar results are found for the related Northside French population of St. Thomas. U.S. Virgin Islands. A recently developed mathematical model predicts the expected effect on heterozygosity of partial or complete avoidance of, or preference for, any combination of consanguineous matings, and also takes into account nonrandom failure to mate. Application of this model to these two populations suggests that under some circumstances nonrandomness in celibacy and emigration may have a greater influence on genotype distributions than does consanguinity avoidance.

URL

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1684887/

Notes

ProCite field[28]: PMC1684887

Reference Type

Journal Article

Journal Title

American Journal of Human Genetics

Author(s)

Leslie, Paul W.
Morrill, Warren T.
Dyke, Bennett

Year Published

1981

Volume Number

33

Issue Number

1

Pages

90-104

PMCID

PMC1684887

Reference ID

3539