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Chandramohan, Daniel; Greenwood, Brian; Cox, Jonathan; Mswia, Robert; & Setel, Philip W. (2001). Relationship between Malaria Endemicity and Acute Febrile Illness Mortality in Children. Bulletin of the World Health Organization, 79(4), 375-376. PMCID: PMC2566399


The relationship between the intensity of malaria transmission and the degree of malaria risk was discussed recently in the Bulletin’s theme section on malaria (1). In their study in the Lancet of hospital admissions in Kenya and the Gambia, Snow et al. (2) found that the cumulative risk of severe malaria by 5 years of age was higher in areas of low-to-moderate transmission (mesoendemic) than in hyperendemic and holoendemic areas (i.e. medium high and high transmission, respectively). They concluded that in highly endemic areas, interventions that reduce transmission of malaria, and thus immunity, might lead to changes in both the clinical spectrum of severe disease and the overall burden of severe malaria morbidity. Recent results from the United Republic of Tanzania do not support this assertion.


Reference Type

Journal Article

Year Published


Journal Title

Bulletin of the World Health Organization


Chandramohan, Daniel
Greenwood, Brian
Cox, Jonathan
Mswia, Robert
Setel, Philip W.