Citation
Herring, Amy H. (2011). Commentary on ‘Antenatal Magnesium Sulphate May Prevent Cerebral Palsy in Preterm Infants-But Are We Convinced? Evaluation of an Apparently Conclusive Meta-Analysis with Trial Sequential Analysis'.
BJOG: An International Journal of Obstetrics & Gynaecology, 118(1), 5.
Abstract
Cerebral palsy is a condition with chronic, nonprogressive disability of the central nervous system, which has major personal and socioeconomic burdens. For preterm infants, the risk of cerebral palsy increases inversely with gestational age at birth. Several studies have indicated that magnesium sulphate given to women at risk of preterm birth may be neuroprotective for the fetus. Meta‐analyses of the data from randomised clinical trials (RCTs), comparing magnesium sulphate against placebo for women at risk of preterm birth, have revealed a significant preventive effect on cerebral palsy in the child without observed serious adverse drug effects. The meta‐analyses found no overall difference in mortality (fetal and later deaths) between the magnesium sulphate and placebo groups.
URL
http://dx.doi.org/10.1111/j.1471-0528.2010.02782.xReference Type
Journal Article
Year Published
2011
Journal Title
BJOG: An International Journal of Obstetrics & Gynaecology
Author(s)
Herring, Amy H.