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Herring, Amy H. (2011). Commentary on ‘Antenatal Magnesium Sulphate May Prevent Cerebral Palsy in Preterm Infants-But Are We Convinced? Evaluation of an Apparently Conclusive Meta-Analysis with Trial Sequential Analysis'. BJOG: An International Journal of Obstetrics & Gynaecology, 118(1), 5.


Cerebral palsy is a condition with chronic, nonprogressive disability of the central nervous system, which has major personal and socioeconomic burdens. For preterm infants, the risk of cerebral palsy increases inversely with gestational age at birth. Several studies have indicated that magnesium sulphate given to women at risk of preterm birth may be neuroprotective for the fetus. Meta‐analyses of the data from randomised clinical trials (RCTs), comparing magnesium sulphate against placebo for women at risk of preterm birth, have revealed a significant preventive effect on cerebral palsy in the child without observed serious adverse drug effects. The meta‐analyses found no overall difference in mortality (fetal and later deaths) between the magnesium sulphate and placebo groups.


Reference Type

Journal Article

Year Published


Journal Title

BJOG: An International Journal of Obstetrics & Gynaecology


Herring, Amy H.