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Antimüllerian Hormone as a Predictor of Natural Fecundability in Women Aged 30-42 Years

Citation

Steiner, Anne Z.; Herring, Amy H.; Kesner, James S.; Meadows, Juliana W.; Stanczyk, Frank Z.; Hoberman, Steven; & Baird, Donna D. (2011). Antimüllerian Hormone as a Predictor of Natural Fecundability in Women Aged 30-42 Years. Obstetrics & Gynecology, 117(4), 798-804. PMCID: PMC3825553

Abstract

OBJECTIVE: To generate estimates of the association between markers of ovarian aging and natural fertility in a community sample at risk for ovarian aging.
METHODS: Women aged 30-44 years with no history of infertility who had been trying to conceive for less than 3 months provided early-follicular phase serum and urine (N=100). Subsequently, these women kept a diary to record menstrual bleeding and intercourse and conducted standardized pregnancy testing for up to 6 months. Serum was analyzed for estradiol, follicle-stimulating hormone (FSH), antimüllerian hormone, and inhibin B. Urine was analyzed for FSH and estrone 3-glucuronide. Diary data on menstrual cycle day and patterns of intercourse were used to calculate day-specific fecundability ratios.
RESULTS: Sixty-three percent of participants conceived within 6 months. After adjusting for age, 18 women (18%) with serum antimüllerian hormone levels of 0.7 ng/mL or less had significantly reduced fecundability given intercourse on a fertile day compared with women with higher antimüllerian hormone levels (fecundability ratio 0.38; 95% confidence interval [CI] 0.08-0.91). The day-specific fecundability for women with early-follicular phase serum FSH values greater than 10 milli-international units/mL compared with women with lower FSH levels was also reduced, although nonsignificantly (11% of women affected; fecundability ratio 0.44; 95% CI 0.08-1.10). The association with urinary FSH was weaker (27% women affected; fecundability ratio 0.61; 95% CI 0.26-1.26), and the associations for the other markers were weaker still.
CONCLUSION: Early-follicular phase antimüllerian hormone appears to be associated with natural fertility in the general population.
LEVEL OF EVIDENCE: II.

URL

http://dx.doi.org/10.1097/AOG.0b013e3182116bc8

Reference Type

Journal Article

Year Published

2011

Journal Title

Obstetrics & Gynecology

Author(s)

Steiner, Anne Z.
Herring, Amy H.
Kesner, James S.
Meadows, Juliana W.
Stanczyk, Frank Z.
Hoberman, Steven
Baird, Donna D.

PMCID

PMC3825553