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Obesity-Susceptibility Loci Have a Limited Influence on Birth Weight: A Meta-Analysis of Up to 28,219 Individuals

Citation

Kilpeläinen, Tuomas O.; den Hoed, Marcel; Ong, Ken K.; Grøntved, Anders; Brage, Soren; Early Growth Genetics (EGG) Consortium, [; Linda S. Adair, Member; ]; Jameson, Karen A.; & Cooper, Cyrus, et al. (2011). Obesity-Susceptibility Loci Have a Limited Influence on Birth Weight: A Meta-Analysis of Up to 28,219 Individuals. American Journal of Clinical Nutrition, 93(4), 851-860.

Abstract

Background: High birth weight is associated with adult body mass index (BMI). We hypothesized that birth weight and BMI may partly share a common genetic background.
Objective: The objective was to examine the associations of 12 established BMI variants in or near the NEGR1, SEC16B, TMEM18, ETV5, GNPDA2, BDNF, MTCH2, BCDIN3D, SH2B1, FTO, MC4R, and KCTD15 genes and their additive score with birth weight.
Design: A meta-analysis was conducted with the use of 1) the European Prospective Investigation into Cancer and Nutrition (EPIC)–Norfolk, Hertfordshire, Fenland, and European Youth Heart Study cohorts (nmax = 14,060); 2) data extracted from the Early Growth Genetics Consortium meta-analysis of 6 genome-wide association studies for birth weight (nmax = 10,623); and 3) all published data (nmax = 14,837).
Results: Only the MTCH2 and FTO loci showed a nominally significant association with birth weight. The BMI-increasing allele of the MTCH2 variant (rs10838738) was associated with a lower birth weight (

URL

http://dx.doi.org/10.3945/ajcn.110.000828

Reference Type

Journal Article

Year Published

2011

Journal Title

American Journal of Clinical Nutrition

Author(s)

Kilpeläinen, Tuomas O.
den Hoed, Marcel
Ong, Ken K.
Grøntved, Anders
Brage, Soren
Early Growth Genetics (EGG) Consortium, [
Linda S. Adair, Member
]
Jameson, Karen A.
Cooper, Cyrus
Khaw, Kay-Tee
Ekelund, Ulf
Wareham, Nicholas J.
Loos, Ruth J. F.