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de Batlle, Jordi; Sauleda, Jaume; Balcells, Eva; Gomez, Federico P.; Mendez, Michelle A.; Rodriguez, Esther; Barreiro, Esther; Ferrer, Jaume J.; Romieu, Isabelle; & Gea, Joaquim, et al. (2012). Association between Omega3 and Omega6 Fatty Acid Intakes and Serum Inflammatory Markers in COPD. Journal of Nutritional Biochemistry, 23(7), 817-821.


Dietary intake of polyunsaturated fatty acids, including omega-3 and omega-6, could modulate chronic obstructive pulmonary disease (COPD) persistent inflammation. We aimed to assess the relationship between dietary intake of omega-3 and omega-6 fatty acids and serum inflammatory markers in COPD. A total of 250 clinically stable COPD patients were included. Dietary data of the last 2 years were assessed using a validated food frequency questionnaire (122 items), which provided levels of three omega-3 fatty acids: docosahexaenoic acid, eicosapentaenoic acid and alpha-linolenic acid (ALA); and two omega-6 fatty acids: linoleic acid and arachidonic acid (AA). Inflammatory markers [C-reactive protein (CRP), interleukin (IL)-6, IL-8 and tumor necrosis factor alpha (TNFalpha)] were measured in serum. Fatty acids and inflammatory markers were dichotomised according to their median values, and their association was assessed using multivariate logistic regression. Higher intake of ALA (an anti-inflammatory omega-3 fatty acid) was associated with lower TNFalpha concentrations [adjusted odds ratio (OR)=0.46; P=.049]. Higher AA intake (a proinflammatory omega-6 fatty acid) was related to higher IL-6 (OR=1.96; P=.034) and CRP (OR=1.95; P=.039) concentrations. Therefore, this study provides the first evidence of an association between dietary intake of omega-3 and omega-6 fatty acids and serum inflammatory markers in COPD patients.


Reference Type

Journal Article

Year Published


Journal Title

Journal of Nutritional Biochemistry


de Batlle, Jordi
Sauleda, Jaume
Balcells, Eva
Gomez, Federico P.
Mendez, Michelle A.
Rodriguez, Esther
Barreiro, Esther
Ferrer, Jaume J.
Romieu, Isabelle
Gea, Joaquim
Anto, Josep M.
Garcia-Aymerich, Judith and the PAC-COPD Study Group,