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Population Versus Customized Fetal Growth Norms and Adverse Outcomes in an Intrapartum Cohort


Costantine, Maged M.; Lai, Yinglei; Bloom, Steven L.; Spong, Catherine Y.; Varner, Michael W.; Rouse, Dwight J.; Ramin, Susan M.; Caritis, Steve N.; Peaceman, Alan M.; & Sorokin, Yoram, et al. (2013). Population Versus Customized Fetal Growth Norms and Adverse Outcomes in an Intrapartum Cohort. American Journal of Perinatology, 30(4), 335-341. PMCID: PMC3622136


Objective: To compare population versus customized fetal growth norms in identifying neonates at risk for adverse outcomes (APO) associated with small for gestational age (SGA).
Study Design: Secondary analysis of an intrapartum fetal pulse oximetry trial in nulliparous women at term. Birth weight percentiles were calculated using ethnicity- and gender-specific population norms and customized norms (Gardosi).
Results: Of the studied neonates, 508 (9.9%) and 584 (11.3%) were SGA by population (SGApop) and customized (SGAcust) norms, respectively. SGApop infants were significantly associated with a composite adverse neonatal outcome, neonatal intensive care admission, low fetal oxygen saturation, and reduced risk of cesarean delivery; both SGApop and SGAcust infants were associated with a 5-minute Apgar score < 4. The ability of customized and population birth weight percentiles in predicting APO was poor (12 of 14 APOs had area under the curve of <0.6).
Conclusion: In this intrapartum cohort, neither customized nor normalized population norms adequately identified neonates at risk of APO related to SGA.


Reference Type

Journal Article

Year Published


Journal Title

American Journal of Perinatology


Costantine, Maged M.
Lai, Yinglei
Bloom, Steven L.
Spong, Catherine Y.
Varner, Michael W.
Rouse, Dwight J.
Ramin, Susan M.
Caritis, Steve N.
Peaceman, Alan M.
Sorokin, Yoram
Sciscione, Anthony C.
Mercer, Brian M.
Thorp, John M., Jr.
Malone, Fergal D.
Harper, Margaret A.
Iams, Jay D., for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network