Maternal Exposure to N-nitrosatable Drugs as a Risk Factor for Childhood Brain Tumors

Citation

Carozza, Susan E.; Olshan, Andrew F.; Faustman, Elaine M.; Gula, Mary J.; Kolonel, Laurence N.; Austin, Donald F.; West, E. Dee; Weiss, Noel S.; Swanson, G. Marie; & Lyon, Joseph L., et al. (1995). Maternal Exposure to N-nitrosatable Drugs as a Risk Factor for Childhood Brain Tumors. International Journal of Epidemiology, 24(2), 308-12.

Abstract

BACKGROUND: Animal models suggest that compounds containing a nitrosyl group (N-nitroso compounds (NNO)) can act as potent transplacental carcinogens. Many common drug formulations have the potential to undergo nitrosation in vivo. The association between maternal use of nitrosatable drugs during pregnancy and development of brain tumours in the offspring was examined in a SEER-based case-control study.

URL

http://dx.doi.org/10.1093/ije/24.2.308

Reference Type

Journal Article

Journal Title

International Journal of Epidemiology

Author(s)

Carozza, Susan E.
Olshan, Andrew F.
Faustman, Elaine M.
Gula, Mary J.
Kolonel, Laurence N.
Austin, Donald F.
West, E. Dee
Weiss, Noel S.
Swanson, G. Marie
Lyon, Joseph L.
Hedley-Whyte, Tessa
Gilles, Floyd H.
Aschenbrener, Carol
Leviton, Alan

Year Published

1995

Volume Number

24

Issue Number

2

Pages

308-12

Reference ID

644