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Occupational Hazards and Pregnancy Outcomes

Citation

Zhang, Jun; Cai, Wen-wei; & Lee, David J. (1992). Occupational Hazards and Pregnancy Outcomes. American Journal of Industrial Medicine, 21(3), 397-408.

Abstract

This study examined the association between exposure to occupational hazards and pregnancy outcomes using data from a case-control study conducted in 29 hospitals in Shanghai, China. The sample included 1,875 perinatal deaths and newborns with birth defects and the same number of controls. Information on mother's exposure to occupational radiation, chemicals, noise, and pesticides was investigated. Logistic regression analysis controlling for potential confounders showed that exposure to radiation before/during pregnancy was associated with antepartum fetal death, birth defects, small-for-gestational-age (SGA), and threatened abortion. Exposure to chemicals before/during pregnancy was associated with antepartum fetal death, early neonatal death, birth defects, preterm birth, and threatened abortion. Women exposed to pesticides during pregnancy had an increased risk of SGA and threatened abortion. Exposure to occupational noise during pregnancy increased the risk of antepartum fetal death. Furthermore, higher than expected numbers of congenital anomalies in the central nervous system (CNS) were identified among women exposed to chemicals before pregnancy and to pesticides during the first trimester of pregnancy. No significant association was found between occupational exposure and intrapartum fetal death. Although recall bias may be possible in our study, the findings encourage further research.

URL

http://dx.doi.org/10.1002/ajim.4700210312

Reference Type

Journal Article

Journal Title

American Journal of Industrial Medicine

Author(s)

Zhang, Jun
Cai, Wen-wei
Lee, David J.

Year Published

1992

Volume Number

21

Issue Number

3

Pages

397-408

Reference ID

66