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Duarte-Salles, Talita; Von Stedingk, Hans; Granum, Berit; Gutzkow, Kristine B.; Rydberg, Per; Tornqvist, Margareta; Mendez, Michelle A.; Brunborg, Gunnar; Brantsaeter, Anne Lise; & Meltzer, Helle Margrete, et al. (2013). Dietary Acrylamide Intake during Pregnancy and Fetal Growth - Results from the Norwegian Mother and Child Cohort Study (MoBa). Environmental Health Perspectives, 121(3), 374-379. PMCID: PMC3621181


BACKGROUND: Acrylamide has shown developmental and reproductive toxicity in animals, as well as neurotoxic effects in humans with occupational exposures. Since it is widespread in food and can pass the human placenta, concerns have been raised about potential developmental effects of dietary exposures in humans.
OBJECTIVES: To assess associations of prenatal exposure to dietary acrylamide with small for gestational age (SGA) and birthweight. METHODS: This study included 50,651 women in the Norwegian Mother and Child Cohort Study (MoBa). Acrylamide exposure assessment was based on intake estimates obtained from a food frequency questionnaire (FFQ) which were compared with hemoglobin (Hb) adduct measurements reflecting acrylamide exposure in a subset of samples (n=79). Data on infant birthweight and gestational age were obtained from the Medical Birth Registry. Multivariable regression was used to estimate associations between prenatal acrylamide and birth outcomes.
RESULTS: Acrylamide intake during pregnancy was negatively associated with fetal growth. When women in the highest quartile of acrylamide intake were compared with women in the lowest quartile, the multivariable-adjusted odds ratio (OR) for SGA was 1.11 (95%CI: 1.02, 1.21) and the coefficient for birthweight was -25.7g (95%CI: -35.9, -15.4). Results were similar after excluding mothers who smoked during pregnancy. Maternal acrylamide- and glycidamide-Hb-adduct levels were correlated with estimated dietary acrylamide intakes (Spearman correlations = 0.24; 95%CI: 0.02, 0.44 and 0.48; 95%CI: 0.29, 0.63, respectively).
CONCLUSIONS: Lowering dietary acrylamide intake during pregnancy may improve fetal growth.


Reference Type

Journal Article

Year Published


Journal Title

Environmental Health Perspectives


Duarte-Salles, Talita
Von Stedingk, Hans
Granum, Berit
Gutzkow, Kristine B.
Rydberg, Per
Tornqvist, Margareta
Mendez, Michelle A.
Brunborg, Gunnar
Brantsaeter, Anne Lise
Meltzer, Helle Margrete
Alexander, Jan
Haugen, Margaretha