Citation
Makelarski, Jennifer A.; Romitti, Paul A.; Sun, Lixian; Burns, Trudy L.; Druschel, Charlotte M.; Suarez, Lucina; Olshan, Andrew F.; Siega-Riz, Anna Maria; & Olney, Richard S., and the National Birth Defects Prevention Study (2013). Periconceptional Maternal Alcohol Consumption and Neural Tube Defects. Birth Defects Research, Part A: Clinical and Molecular Teratology, 97(3), 152-160. PMCID: PMC4435553Abstract
BACKGROUND: Neural tube defects (NTD)s, which occur when the neural tube fails to close during early gestation, are some of the most common birth defects worldwide. Alcohol is a known teratogen and has been shown to induce NTDs in animal studies, although most human studies have failed to corroborate these results. Using data from the National Birth Defects Prevention Study, associations between maternal reports of periconceptional (1 month prior through 2 months postconception) alcohol consumption and NTDs were examined.METHODS: NTD cases and unaffected live born control infants, delivered from 1997 through 2005, were included. Interview reports of alcohol consumption (quantity, frequency, variability, and type) were obtained from 1223 case mothers and 6807 control mothers. Adjusted odds ratios (aOR)s and 95% confidence intervals were estimated using multivariable logistic regression analysis.
RESULTS: For all NTDs combined, most aORs for any alcohol consumption, one or more binge episodes, and different type(s) of alcohol consumed were near unity or modestly reduced (≥0.7
URL
http://dx.doi.org/10.1002/bdra.23122Reference Type
Journal ArticleYear Published
2013Journal Title
Birth Defects Research, Part A: Clinical and Molecular TeratologyAuthor(s)
Makelarski, Jennifer A.Romitti, Paul A.
Sun, Lixian
Burns, Trudy L.
Druschel, Charlotte M.
Suarez, Lucina
Olshan, Andrew F.
Siega-Riz, Anna Maria
Olney, Richard S., and the National Birth Defects Prevention Study
PMCID
PMC4435553ORCiD
Olshan - 0000-0001-9115-5128Siega-Riz - 0000-0002-1303-4248