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Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained

Citation

Wu, Ying; Waite, Lindsay L.; Jackson, Anne U.; Sheu, Wayne Huey-Herng; Buyske, Steven G.; Absher, Devin M.; Arnett, Donna K.; Boerwinkle, Eric A.; Bonnycastle, Lori L.; & Carty, Cara L., et al. (2013). Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained. PLOS Genetics, 9(3), e1003379. PMCID: PMC3605054

Abstract

Lipid traits are heritable, but many of the DNA variants that influence lipid levels remain unknown. In a genomic region, more than one variant may affect gene expression or function, and the frequencies of these variants can differ across populations. Genotyping densely spaced variants in individuals with different ancestries may increase the chance of identifying variants that affect gene expression or function. We analyzed high-density genotyped variants for association with TG, HDL-C, and LDL-C in African Americans, East Asians, and Europeans. At several genomic regions, we provide evidence that two or more variants can influence lipid traits; across loci, these additional signals increase the proportion of trait variation that can be explained by genes. At some association signals shared across populations, combining data from individuals of different ancestries narrowed the set of likely functional variants. At

URL

http://dx.doi.org/10.1371%2Fjournal.pgen.1003379

Reference Type

Journal Article

Year Published

2013

Journal Title

PLOS Genetics

Author(s)

Wu, Ying
Waite, Lindsay L.
Jackson, Anne U.
Sheu, Wayne Huey-Herng
Buyske, Steven G.
Absher, Devin M.
Arnett, Donna K.
Boerwinkle, Eric A.
Bonnycastle, Lori L.
Carty, Cara L.
Cheng, Iona
Cochran, Barbara J.
Croteau-Chonka, Damien C.
Dumitrescu, Logan C.
Eaton, Charles B.
Franceschini, Nora
Guo, Xiuqing
Henderson, Brian E.
Hindorff, Lucia A.
Kim, Eric
Kinnunen, Leena
Komulainen, Pirjo
Lee, Wen-Jane
Le Marchand, Loic
Lin, Yi
Lindström, Jaana
Lingaas-Holmen, Oddgeir L.
Mitchell, Sabrina L.
Narisu, Narisu
Robinson, Jennifer G.
Schumacher, Fredrick R.
Stančáková, Alena
Sundvall, Jouko
Sung, Yun J.
Swift, Amy J.
Wang, Wen-Chang
Wilkens, Lynne R.
Wilsgaard, Tom
Young, Alicia M.
Adair, Linda S.
Ballantyne, Christie M.
Bůžková, Petra
Chakravarti, Aravinda
Collins, Francis S.
Duggan, David
Feranil, Alan B.
Ho, Low-Tone
Hung, Yi-Jen
Hunt, Steven C.
Hveem, Kristian
Juang, Jyh-Ming J.
Kesäniemi, Antero Y.
Kuusisto, Johanna
Laakso, Markku
Lakka, Timo A.
Lee, I-Te
Leppert, Mark F.
Matise, Tara C.
Moilanen, Leena
Njølstad, Inger
Peters, Ulrike
Quertermous, Thomas
Rauramaa, Rainer
Rotter, Jerome I.
Saramies, Jouko
Tuomilehto, Jaakko
Uusitupa, Matti
Wang, Tzung-Dau
Boehnke, Michael
Haiman, Christopher A.
Chen, Yii-Der Ida
Kooperberg, Charles L.
Assimes, Themistocles L.
Crawford, Dana C.
Hsiung, Chao A.
North, Kari E.
Mohlke, Karen L.

PMCID

PMC3605054