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Prenatal Bisphenol A Urine Concentrations and Early Rapid Growth and Overweight Risk in the Offspring


Valvi, Damaskini; Casas, Maribel; Mendez, Michelle A.; Ballesteros-Gomez, Ana; Luque, Noelia; Rubio, Soledad; Sunyer, Jordi; & Vrijheid, Martine (2013). Prenatal Bisphenol A Urine Concentrations and Early Rapid Growth and Overweight Risk in the Offspring. Epidemiology, 24(6), 791-799.


BACKGROUND: Increasing experimental evidence suggests that prenatal bisphenol A (BPA) exposure induces offspring weight gain, but these effects remain largely unexplored in humans. We examined the effects of prenatal BPA exposure on postnatal growth and obesity.
METHODS: BPA concentrations were measured in two spot-urine samples collected in the 1st and 3rd trimesters of pregnancy from mothers in a Spanish birth cohort study (n = 402). We used the average of the two creatinine-adjusted BPA concentrations as the exposure variable. Rapid child growth was defined as a weight gain Z score >0.67 in the first 6 months of life. Age- and sex-specific Z scores for body mass index (BMI) were calculated at age 14 months and 4 years, based on the World Health Organization referent; overweight was defined as a BMI Z score greater than or equal to the 85th percentile. Age- and sex-specific waist circumference Z scores were calculated at age 14 months and 4 years using the analysis population mean.
RESULTS: Twenty-six percent of children were rapid growers; 25% were overweight at 14 months and 21% at 4 years. Geometric mean BPA concentrations were 2.6 mug/g creatinine (standard deviation = 2.3) in 1st trimester and 2.0 (2.3) in 3rd trimester samples (Pearson r = 0.13). At 4 years, BPA exposure was associated with increased waist circumference (beta per log10 mug/g = 0.28 [95% confidence interval = 0.01 to 0.57]) and BMI (beta = 0.28 [-0.06 to 0.63]). BPA was not associated with obesity-related outcomes at earlier ages.
CONCLUSIONS: This study provides some evidence for an association between prenatal BPA exposure and obesity-related outcomes in childhood, although not in infancy. The large uncertainties in BPA exposure assessment require that findings be interpreted with caution.


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Valvi, Damaskini
Casas, Maribel
Mendez, Michelle A.
Ballesteros-Gomez, Ana
Luque, Noelia
Rubio, Soledad
Sunyer, Jordi
Vrijheid, Martine