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Predictors of Inflammation in U.S. Children Aged 3-16 Years

Citation

Dowd, Jennifer Beam; Zajacova, Anna; & Aiello, Allison E. (2010). Predictors of Inflammation in U.S. Children Aged 3-16 Years. American Journal of Preventive Medicine, 39(4), 314-320. PMCID: PMC2952932

Abstract

BACKGROUND: Little is known about the correlates of low-grade inflammation in U.S. children.
PURPOSE: This study describes the factors associated with increased levels of C-reactive protein (CRP) in U.S. children and tests whether differences in CRP emerge in childhood because of socioeconomic factors.
METHODS: Data were analyzed in 2009 from 6004 children aged 3-16 years from the National Health and Nutrition Examination Survey, 1999-2004, a representative sample of the U.S. non-institutionalized population. Tobit regression models are used to evaluate associations between predictors, including BMI-for-age, skinfold body fat measures, chronic infections, environmental tobacco exposure, low birth weight, and sociodemographics and continuous high-sensitivity CRP in milligrams per liter.
RESULTS: CRP levels were higher in U.S. children with lower family income, and these differences were largely accounted for by differences in adiposity and recent illness. Mexican-American children had higher levels of CRP compared to both whites and blacks, but these differences were not explained by measured physical risk factors.
CONCLUSIONS: Increased adiposity is associated with higher CRP concentrations in U.S children aged 3-16 years, and both socioeconomic and racial/ethnic differences exist in systemic inflammation in U.S. children. Increased childhood obesity and low-grade inflammation may contribute to later life chronic disease risk.

URL

http://dx.doi.org/10.1016/j.amepre.2010.05.014

Reference Type

Journal Article

Year Published

2010

Journal Title

American Journal of Preventive Medicine

Author(s)

Dowd, Jennifer Beam
Zajacova, Anna
Aiello, Allison E.

PMCID

PMC2952932