Determinants of the Transition from a Cardiometabolic Normal to Abnormal Overweight/Obese Phenotype in a Spanish Population

Citation

Schroder, Helmut; Ramos, Rafael; Baena-Diez, Jose M.; Mendez, Michelle A.; Canal, Dolors Juvinya; Fito, Montserrat; Sala, Joan; & Elosua, Roberto (2014). Determinants of the Transition from a Cardiometabolic Normal to Abnormal Overweight/Obese Phenotype in a Spanish Population. European Journal of Nutrition, 53(6), 1345-1353.

Abstract

PURPOSE: There is limited prospective evidence at population scale of the impacts of lifestyle and surrogate measures of general and abdominal adiposity on the transition of a metabolically healthy (absence of a metabolic disorder) overweight/obese (MHOO) phenotype to a metabolically abnormal overweight/obese (MAOO) phenotype. Therefore, we determined the relationship between 10-year body mass index (BMI), waist circumferences (WC), waist to height ratio (WHtR), and lifestyle changes and the transition of the MHOO phenotype.
METHODS: We conducted a prospective population-based study of 3,052 male and female Spaniards aged 25-74 years who were followed from 2000 through 2009. Diet and leisure-time physical activity were recorded on validated questionnaires. Weight, height, WC, blood lipids, glycemia, and blood pressure were measured. All variables were obtained at baseline (BL) and follow-up (FL). Participants with a BMI >/= 25 kg/m(2) and free from hypercholesterolemia, hypertriglyceridemia, diabetes, hypertension, and low HDL and high LDL cholesterol levels were characterized as the MHOO phenotype. A composite healthy lifestyle index (HLI) was constructed by including temporary changes in 3 lifestyle variables (diet, leisure-time physical activity, and smoking).
RESULTS: Initially, 20.8 % of subjects had the MHOO phenotype; 49.2 % of these shifted to MAOO phenotype. In multivariate analysis, changes in BMI, WC, WHtR were positively associated (p = 0.004, p = 0.018, and p = 0.016, respectively) with this transition. One unit increase in the HLI was associated with a 33 % lower risk (p = 0.025) to the MAOO phenotype transition after adjusting for age, sex, educational level, and baseline energy intake, BMI, WC, and WHtR.
CONCLUSIONS: The presence of metabolic disorders in the MHOO phenotype is predicted by an increase in anthropometric surrogate measures of general and abdominal adiposity. In contrast, a healthy lifestyle protects against a transition to the MAOO phenotype.

URL

http://dx.doi.org/10.1007/s00394-013-0635-2

Reference Type

Journal Article

Year Published

2014

Journal Title

European Journal of Nutrition

Author(s)

Schroder, Helmut
Ramos, Rafael
Baena-Diez, Jose M.
Mendez, Michelle A.
Canal, Dolors Juvinya
Fito, Montserrat
Sala, Joan
Elosua, Roberto