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Horton, Amanda L.; Lai, Yinglei; Rouse, Dwight J.; Spong, Catherine Y.; Leveno, Kenneth J.; Varner, Michael W.; Mercer, Brian M.; Iams, Jay D.; Wapner, Ronald J.; & Sorokin, Yoram, et al. (2015). Effect of Magnesium Sulfate Administration for Neuroprotection on Latency in Women with Preterm Premature Rupture of Membranes. American Journal of Perinatology, 32(4), 387-392. PMCID: PMC4369158


OBJECTIVE: To evaluate whether magnesium sulfate administration for neuroprotection prolongs latency in women with preterm premature rupture of membranes between 24 and 31 6/7 weeks' gestation.
STUDY DESIGN: This is a secondary analysis of a randomized controlled trial of magnesium sulfate for prevention of cerebral palsy. Gravid women with a singleton pregnancy between 24 and 31 6/7 weeks' gestation with preterm premature rupture of membranes (pPROM) without evidence of labor were randomized to receive magnesium sulfate, administered intravenously as a 6-g bolus followed by a constant infusion of 2 g per hour up to 12 hours, or placebo. Maternal outcomes for this analysis were delivery in less than 48 hours and in less than 7 days from randomization. Neonatal outcomes included a composite of respiratory distress, interventricular hemorrhage grades 3 or 4, periventricular leukomalacia, sepsis, necrotizing enterocolitis, retinopathy of prematurity, or death.
RESULTS: A total of 1259 women were included. The rate of delivery < 48 hours was not different in the magnesium sulfate and the placebo groups (22.2% and 20.7%, p=0.51). Delivery < 7 days was similar between groups (55.4% and 51.4%, p=0.16). Median latency was also similar between groups (median [interquartile range] 6.0 days [2.4–13.8] and 6.6 days [2.4–15.1], p =0.29). Composite neonatal outcomes did not differ between groups.
CONCLUSION: Magnesium sulfate administration given for neuroprotection in women with a singleton gestation with preterm premature rupture of membranes and without labor before 32 weeks does not impact latency.


Reference Type

Journal Article

Year Published


Journal Title

American Journal of Perinatology


Horton, Amanda L.
Lai, Yinglei
Rouse, Dwight J.
Spong, Catherine Y.
Leveno, Kenneth J.
Varner, Michael W.
Mercer, Brian M.
Iams, Jay D.
Wapner, Ronald J.
Sorokin, Yoram
Ramin, Susan M.
Malone, Fergal D.
O'Sullivan, Mary Jo
Hankins, Gary D. V.
Steve N. Caritis for the Eunice Kennedy Shriver National Institute of Child Health Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network [
John M. Thorp, Jr., Member