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Basraon, Sanmaan K.; Mele, Lisa; Myatt, Leslie; Roberts, James M.; Hauth, John C.; Leveno, Kenneth J.; Varner, Michael W.; Wapner, Ronald J.; Peaceman, Alan M.; & Ramin, Susan M., et al. (2016). Relationship of Early Pregnancy Waist-to-Hip Ratio versus Body Mass Index with Gestational Diabetes Mellitus and Insulin Resistance. American Journal of Perinatology, 33(1), 114-122. PMCID: PMC5283057


Objective: To determine the risk of gestational diabetes mellitus (GDM) and insulin resistance (IR) in obesity defined by body mass index (BMI), waist-to-hip ratio (WHR), or both combined.
Methods: Secondary analysis of a randomized multicenter trial of antioxidant supplementation versus placebo in nulliparous low-risk women to prevent pregnancy associated hypertension. Women between 9 and 16 weeks with data for WHR and BMI were analyzed for GDM (n = 2,300). Those with fasting glucose and insulin between 22 and 26 weeks (n = 717) were analyzed for IR by homeostatic model assessment of IR (normal,


Reference Type

Journal Article

Year Published


Journal Title

American Journal of Perinatology


Basraon, Sanmaan K.
Mele, Lisa
Myatt, Leslie
Roberts, James M.
Hauth, John C.
Leveno, Kenneth J.
Varner, Michael W.
Wapner, Ronald J.
Peaceman, Alan M.
Ramin, Susan M.
Sciscione, Anthony C.
Tolosa, Jorge E.
Sorokin, Yoram, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network [John M. Thorp, Jr., Member]