Early Life Antibiotic Exposure Is Not Associated with Growth in Young Children of Vellore, India

Citation

Rogawski, Elizabeth T.; Westreich, Daniel J.; Adair, Linda S.; Becker-Dreps, Sylvia I.; Sandler, Robert S.; Sarkar, Rajiv; Kattula, Deepthi; Ward, Honorine D.; Meshnick, Steven R.; & Kang, Gagandeep (2015). Early Life Antibiotic Exposure Is Not Associated with Growth in Young Children of Vellore, India. Journal of Pediatrics, 167(5), 1096-102.e3. PMCID: PMC5030490

Abstract

Objectives: To estimate the effects of antibiotic exposures in the first 6 months of life on short- and long-term growth. Study design in a prospective observational cohort study of 497 children from Vellore, India, we estimated short-term effects of antibiotics during the first 6 months using longitudinal general linear regression to model weight-for-age, height-for-age, and weight-for-height z-scores in monthly intervals. To estimate long-term effects, we modeled growth from 6 months to 3 years as a function of antibiotic use in the first 6 months. We also estimated the effects of antibiotics on the monthly relative risks of underweight, stunting, and wasting in the first 6 months and to 3 years. Results: Underweight, stunting, and wasting were common in this population: 31%, 32%, and 15% on average after 6 months of age, respectively. There was no association between antibiotic exposures before 6 months and growth during that period. From 6 months to 3 years, adjusted absolute differences in weight and height were small (approximately

URL

http://dx.doi.org/10.1016/j.jpeds.2015.08.015

Reference Type

Journal Article

Year Published

2015

Journal Title

Journal of Pediatrics

Author(s)

Rogawski, Elizabeth T.
Westreich, Daniel J.
Adair, Linda S.
Becker-Dreps, Sylvia I.
Sandler, Robert S.
Sarkar, Rajiv
Kattula, Deepthi
Ward, Honorine D.
Meshnick, Steven R.
Kang, Gagandeep

PMCID

PMC5030490

ORCiD

Adair - 0000-0002-3670-8073