Menu Close

Genetic Variations in Vitamin D-Related Pathways and Breast Cancer Risk in African American Women in the AMBER Consortium

Citation

Yao, Song; Haddad, Stephen A.; Hu, Qiang; Liu, Song; Lunetta, Kathryn L.; Ruiz-Narvaez, Edward A.; Hong, Chi-Chen; Zhu, Qianqian; Sucheston-Campbell, Lara E.; & Cheng, Ting-Yuan David, et al. (2016). Genetic Variations in Vitamin D-Related Pathways and Breast Cancer Risk in African American Women in the AMBER Consortium. International Journal of Cancer, 138(9), 2118-2126. PMCID: PMC5087916

Abstract

Studies of genetic variations in vitamin D-related pathways and breast cancer risk have been conducted mostly in populations of European ancestry, and only sparsely in African Americans (AA), who are known for a high prevalence of vitamin D deficiency. We analyzed 24,445 germline variants in 63 genes from vitamin D-related pathways in the African American Breast Cancer Epidemiology and Risk (AMBER) consortium, including 3,663 breast cancer cases and 4,687 controls. Odds ratios (OR) were derived from logistic regression models for overall breast cancer, by estrogen receptor (ER) status (1,983 ER positive and 1,098 ER negative), and for case-only analyses of ER status. None of the three vitamin D-related pathways were associated with breast cancer risk overall or by ER status. Gene-level analyses identified associations with risk for several genes at a nominal p

URL

http://dx.doi.org/10.1002/ijc.29954

Reference Type

Journal Article

Year Published

2016

Journal Title

International Journal of Cancer

Author(s)

Yao, Song
Haddad, Stephen A.
Hu, Qiang
Liu, Song
Lunetta, Kathryn L.
Ruiz-Narvaez, Edward A.
Hong, Chi-Chen
Zhu, Qianqian
Sucheston-Campbell, Lara E.
Cheng, Ting-Yuan David
Bensen, Jeannette T.
Johnson, Candace S.
Trump, Donald L.
Haiman, Christopher A.
Olshan, Andrew F.
Palmer, Julie R.
Ambrosone, Christine B.

PMCID

PMC5087916