Vehicular Traffic-Related Polycyclic Aromatic Hydrocarbon Exposure and Breast Cancer Incidence: The Long Island Breast Cancer Study Project (LIBCSP)

Citation

Mordukhovich, Irina; Beyea, Jan; Herring, Amy H.; Hatch, Maureen; Stellman, Steven D.; Teitelbaum, Susan L.; Richardson, David B.; Millikan, Robert C.; Engel, Lawrence S.; & Shantakumar, Sumitra, et al. (2016). Vehicular Traffic-Related Polycyclic Aromatic Hydrocarbon Exposure and Breast Cancer Incidence: The Long Island Breast Cancer Study Project (LIBCSP). Environmental Health Perspectives, 124(1), 30-38. PMCID: PMC4710589

Abstract

BACKGROUND: Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental pollutants, known human lung carcinogens, and potent mammary carcinogens in laboratory animals. However, the association between PAHs and breast cancer in women is unclear. Vehicular traffic is a major ambient source of PAH exposure.
OBJECTIVES: Our study aim was to evaluate the association between residential exposure to vehicular traffic and breast cancer incidence.
METHODS: Residential histories of 1,508 participants with breast cancer (case participants) and 1,556 participants with no breast cancer (control participants) were assessed in a population-based investigation conducted in 1996–1997. Traffic exposure estimates of benzo[a]pyrene (B[a]P), as a proxy for traffic-related PAHs, for the years 1960–1995 were reconstructed using a model previously shown to generate estimates consistent with measured soil PAHs, PAH–DNA adducts, and CO readings. Associations between vehicular traffic exposure estimates and breast cancer incidence were evaluated using unconditional logistic regression.
RESULTS: The odds ratio (95% CI) was modestly elevated by 1.44 (0.78, 2.68) for the association between breast cancer and long-term 1960–1990 vehicular traffic estimates in the top 5%, compared with below the median. The association with recent 1995 traffic exposure was elevated by 1.14 (0.80, 1.64) for the top 5%, compared with below the median, which was stronger among women with low fruit/vegetable intake [1.46 (0.89, 2.40)], but not among those with high fruit/vegetable intake [0.92 (0.53, 1.60)]. Among the subset of women with information regarding traffic exposure and tumor hormone receptor subtype, the traffic–breast cancer association was higher for those with estrogen/progesterone-negative tumors [1.67 (0.91, 3.05) relative to control participants], but lower among all other tumor subtypes [0.80 (0.50, 1.27) compared with control participants].
CONCLUSIONS: In our population-based study, we observed positive associations between vehicular traffic-related B[a]P exposure and breast cancer incidence among women with comparatively high long-term traffic B[a]P exposures, although effect estimates were imprecise.

URL

http://dx.doi.org/10.1289/ehp.1307736

Reference Type

Journal Article

Year Published

2016

Journal Title

Environmental Health Perspectives

Author(s)

Mordukhovich, Irina
Beyea, Jan
Herring, Amy H.
Hatch, Maureen
Stellman, Steven D.
Teitelbaum, Susan L.
Richardson, David B.
Millikan, Robert C.
Engel, Lawrence S.
Shantakumar, Sumitra
Steck, Susan E.
Neugut, Alfred I.
Rossner, Pavel, Jr.
Santella, Regina M.
Gammon, Marilie D.

PMCID

PMC4710589