Citation
Sauder, Katherine A.; Starling, Anne P.; Shapiro, Allison L.; Kaar, Jill Landsbaugh; Ringham, Brandy M.; Glueck, Deborah H.; Leiferman, Jennifer A.; Siega-Riz, Anna Maria; & Dabelea, Dana (2016). Diet, Physical Activity and Mental Health Status Are Associated with Dysglycaemia in Pregnancy: The Healthy Start Study. Diabetic Medicine, 33(5), 663-667. PMCID: PMC4883104Abstract
AIMS: To examine the association between dysglycaemia and multiple modifiable factors measured during pregnancy.METHODS: The Healthy Start Study collected self-reported data on modifiable factors in early and mid-pregnancy (median 17 and 27 weeks gestation, respectively) from 832 women. Women received one point for each modifiable factor for which they had optimum scores: diet quality (Healthy Eating Index score >/=64), physical activity level (estimated energy expenditure >/=170 metabolic equivalent task-h/week), and mental health status (Perceived Stress Scale score <6 and Edinburgh Postnatal Depression Scale score <13). Dysglycaemia during pregnancy was defined as an abnormal glucose challenge result, >/=1 abnormal results on an oral glucose tolerance test, or a clinical diagnosis of gestational diabetes. Logistic regression models estimated odds ratios for dysglycaemia as a function of each factor and the total score, adjusted for age, race/ethnicity, pre-pregnancy BMI, history of gestational diabetes, and family history of Type 2 diabetes.
RESULTS: In individual analyses, only physical activity was significantly associated with a reduced risk of dysglycaemia (adjusted odds ratio 0.67, 95% CI 0.44-1.00). We observed a significant, dose-response association between increasing numbers of optimal factors and odds of dysglycaemia (adjusted P=0.01). Compared with having no optimal modifiable factors, having all three was associated with a 73% reduced risk of dysglycaemia (adjusted odds ratio 0.27, 95% CI 0.08-0.95).
CONCLUSIONS: An increasing number of positive modifiable factors in pregnancy was associated with a dose-response reduction in risk of dysglycaemia. Our results support the hypothesis that modifiable factors in pregnancy are associated with the risk of prenatal dysglycaemia.
URL
http://dx.doi.org/10.1111/dme.13093Reference Type
Journal ArticleYear Published
2016Journal Title
Diabetic MedicineAuthor(s)
Sauder, Katherine A.Starling, Anne P.
Shapiro, Allison L.
Kaar, Jill Landsbaugh
Ringham, Brandy M.
Glueck, Deborah H.
Leiferman, Jennifer A.
Siega-Riz, Anna Maria
Dabelea, Dana