Citation
Aiello, Allison E.; Feinstein, Lydia; Dowd, Jennifer Beam; Pawelec, Graham; Derhovanessian, Evelyna; Galea, Sandro; Uddin, Monica; Wildman, Derek E.; & Simanek, Amanda M. (2016). Income and Markers of Immunological Cellular Aging. Psychosomatic Medicine, 78(6), 657-666. PMCID: PMC4927391Abstract
Objective: Socioeconomic disadvantage may contribute to poor health through immune-related biological mechanisms. We examined the associations between socioeconomic status, as measured by annual household income, and T-cell markers of aging, including the ratios of CD4 and CD8 effector cells to naive cells (E/N ratio) and the CD4/CD8 T-cell ratio. We hypothesized that participants with a lower income would have higher E/N ratios and lower CD4/CD8 ratios compared with participants with a higher income, and that these associations would be partially mediated by elevated cytomegalovirus (CMV) IgG antibody levels, a virus implicated in aging and clonal expansion of T cells.Methods: Data were from 79 individuals who participated in the population-based Detroit Neighborhood Health Study. We used linear regression to quantify the association between a $10,000 decrease in income and each ratio outcome.
Results: After adjustment for age, sex, race, smoking, medication use, and lifetime history of mental health conditions, lower income was associated with a 0.41 (95% confidence interval = 0.09-0.72) log-unit increase in the CD4 E/N ratio and a 0.20 (95% confidence interval = 0.02-0.39) log-unit increase in the CD8 E/N ratio. CMV immunoglobulin G antibody level partially mediated these associations.
Conclusions: Our study suggests that low socioeconomic status is associated with immunological aging as measured by the E/N ratio and that impaired immune control of CMV may partially mediate these associations.
URL
http://dx.doi.org/10.1097/PSY.0000000000000320Reference Type
Journal ArticleYear Published
2016Journal Title
Psychosomatic MedicineAuthor(s)
Aiello, Allison E.Feinstein, Lydia
Dowd, Jennifer Beam
Pawelec, Graham
Derhovanessian, Evelyna
Galea, Sandro
Uddin, Monica
Wildman, Derek E.
Simanek, Amanda M.