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Carbon Black Risk Assessment Comparison Is Flawed

Citation

Hertz-Picciotto, Irva; Korte, Jeffrey E.; Schulz, Mark R.; Chiang, Tung-Chin; & Ball, Louise M. (1997). Carbon Black Risk Assessment Comparison Is Flawed. Regulatory Toxicology and Pharmacology, 26(3), 338-9.

Abstract

Although the effort of Valberg and Watson (1996) to incorporate epidemiologic data into an assessment of the plausibility of carcinogenicity estimates is to be commended, their analysis contains a fundamental flaw. The authors equate comparison of observed rates with expected rates, a common technique in epidemiology, to a comparison of the number of observed events with an expected number of events. The two comparisons arenotequivalent. The only circumstance in which they are equivalent is when the same denominator of person-time produces both the observed and the expected events.

URL

http://dx.doi.org/10.1006/rtph.1997.9998

Reference Type

Journal Article

Journal Title

Regulatory Toxicology and Pharmacology

Author(s)

Hertz-Picciotto, Irva
Korte, Jeffrey E.
Schulz, Mark R.
Chiang, Tung-Chin
Ball, Louise M.

Year Published

1997

Volume Number

26

Issue Number

3

Pages

338-9

Reference ID

951