CitationSheahan, Anna; Feinstein, Lydia; Dube, Queen; Edmonds, Andrew; Chirambo, Chawanangwa Mahebere; Smith, Emily R.; Behets, Frieda M.-T. F.; Heyderman, Robert; & Van Rie, Annelies T. (2017). Early Antiretroviral Therapy Initiation and Mortality among Infants Diagnosed with HIV in the First 12 Weeks of Life: Experiences from Kinshasa, DR Congo and Blantyre, Malawi. Pediatric Infectious Disease Journal, 36(7), 654-658. PMCID: PMC5468473
AbstractBACKGROUND: Based on clinical trial results, the WHO recommends infant HIV testing at age 4-6 weeks and immediate antiretroviral therapy (ART) initiation in all HIV-infected infants. Little is known about the outcomes of HIV infected infants diagnosed with HIV in the first weeks of life in resource-limited settings. We assessed ART initiation and mortality in the first year of life among infants diagnosed with HIV by 12 weeks of age.
METHODS: Cohort of HIV-infected infants in Kinshasa and Blantyre diagnosed before 12 weeks to estimate 12-month cumulative incidences of ART initiation and mortality, accounting for competing risks. Multivariate models were used to estimate associations between infant characteristics and timing of ART initiation.
RESULTS: 121 infants were diagnosed at a median age of 7 weeks (interquartile range 6-8). The cumulative incidence of ART initiation was 46% (95% CI: 36%, 55%) at 6 months and 70% (95% CI: 60%, 78%) at 12 months. Only age at HIV diagnosis was associated with ART initiation by age 6 months, with a subdistribution hazard ratio of 0.70 (95% CI: 0.52, 0.91) for each week increase in age at DNA PCR test. The 12-month cumulative incidence of mortality was 20% (95% CI: 13%, 28%).
CONCLUSIONS: Despite early diagnosis of HIV, ART initiation was slow and mortality remained high, underscoring the complexity in translating clinical trial findings and WHO guidance into real-life practice. Novel and creative health system interventions will be required to ensure that all HIV infected infants achieve optimal treatment outcomes under routine care settings.
Reference TypeJournal Article
Journal TitlePediatric Infectious Disease Journal
Chirambo, Chawanangwa Mahebere
Smith, Emily R.
Behets, Frieda M.-T. F.
Van Rie, Annelies T.