Citation
Bauer, Anna E.; Avery, Christy L.; Shi, Min; Weinberg, Clarice R.; Olshan, Andrew F.; Harmon, Quaker E.; Luo, Jingchun; Yang, Jenny; Manuck, Tracy A.; & Wu, Michael C., et al. (2024). Do Genetic Variants Modify the Effect of Smoking on Risk of Preeclampsia in Pregnancy?. American Journal of Perinatology, 41(1), 44-52. PMCID: PMC10127527Abstract
OBJECTIVE: Maternal smoking is associated with as much as a 50% reduced risk of preeclampsia, despite increasing risk of other poor pregnancy outcomes that often co-occur with preeclampsia, such as preterm birth and fetal growth restriction. Researchers have long sought to understand whether this perplexing association is biologically based, or a result of noncausal mechanisms. We examined whether smoking-response genes modify the smoking-preeclampsia association to investigate potential biological explanations.STUDY DESIGN: We conducted a nested case-control study within the Norwegian Mother, Father and Child Birth Cohort (1999-2008) of 2,596 mother-child dyads. We used family-based log-linear Poisson regression to examine modification of the maternal smoking-preeclampsia relationship by maternal and fetal single nucleotide polymorphisms involved in cellular processes related to components of cigarette smoke (n = 1,915 with minor allele frequency
URL
http://dx.doi.org/10.1055/s-0041-1740072Reference Type
Journal ArticleYear Published
2024Journal Title
American Journal of PerinatologyAuthor(s)
Bauer, Anna E.Avery, Christy L.
Shi, Min
Weinberg, Clarice R.
Olshan, Andrew F.
Harmon, Quaker E.
Luo, Jingchun
Yang, Jenny
Manuck, Tracy A.
Wu, Michael C.
Klungsøyr, Kari
Trogstad, Lill
Magnus, Per M.
Engel, Stephanie M.
Article Type
RegularPMCID
PMC10127527Data Set/Study
Norwegian Mother, Father and Child Birth Cohort StudyContinent/Country
NorwayORCiD
Olshan - 0000-0001-9115-5128Avery - 0000-0002-1044-8162