Maternal Adverse Childhood Experiences (ACEs) and Offspring Imprinted Gene DMR Methylation at Birth

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Citation

Vidal, Adriana C.; Sosnowski, David W.; Marchesoni, Joddy; Grenier, Carole; Thorp, John M., Jr.; Murphy, Susan K.; Johnson, Sara B.; Schlief, Billy; & Hoyo, Cathrine (2024). Maternal Adverse Childhood Experiences (ACEs) and Offspring Imprinted Gene DMR Methylation at Birth. Epigenetics, 19(1), 2293412. PMCID: PMC10730185

Abstract

Adverse childhood experiences (ACEs) contribute to numerous negative health outcomes across the life course and across generations. Here, we extend prior work by examining the association of maternal ACEs, and their interaction with financial stress and discrimination, with methylation status within eight differentially methylated regions (DMRs) in imprinted domains in newborns. ACEs, financial stress during pregnancy, and experience of discrimination were self-reported among 232 pregnant women. DNA methylation was assessed at PEG10/SGCE, NNAT, IGF2, H19, PLAGL1, PEG3, MEG3-IG, and DLK1/MEG3 regulatory sequences using pyrosequencing. Using multivariable linear regression models, we found evidence to suggest that financial stress was associated with hypermethylation of MEG3-IG in non-Hispanic White newborns; discrimination was associated with hypermethylation of IGF2 and NNAT in Hispanic newborns, and with hypomethylation of PEG3 in non-Hispanic Black newborns. We also found evidence that maternal ACEs interacted with discrimination to predict offspring PLAGL1 altered DMR methylation, in addition to interactions between maternal ACEs score and discrimination predicting H19 and SGCE/PEG10 altered methylation in non-Hispanic White newborns. However, these interactions were not statistically significant after multiple testing corrections. Findings from this study suggest that maternal ACEs, discrimination, and financial stress are associated with newborn aberrant methylation in imprinted gene regions.

URL

http://dx.doi.org/10.1080/15592294.2023.2293412

Reference Type

Journal Article

Year Published

2024

Journal Title

Epigenetics

Author(s)

Vidal, Adriana C.
Sosnowski, David W.
Marchesoni, Joddy
Grenier, Carole
Thorp, John M., Jr.
Murphy, Susan K.
Johnson, Sara B.
Schlief, Billy
Hoyo, Cathrine

Article Type

Regular

PMCID

PMC10730185

Data Set/Study

Stress and Health in Pregnancy (SHIP) Study
Prospective Research on Early Determinants of Illness and Children’s Health Trajectories (PREDICT) Study

Continent/Country

United States

State

Florida
North Carolina

Race/Ethnicity

Hispanic
Black
White

ORCiD

Thorp - 0000-0002-9307-6690