Clinical trial with the levonorgestrel intrauterine system to measure changes in hemoglobin and serum ferritin among anemic women in Kenya
Summary
The proposed randomized trial aims to form two cohorts from a population of anemic women seeking contraception in Nairobi, Kenya: LNG IUS users and users of oral contraceptives. Women aged 18-44 with back-to-back hemoglobin measures between 87 and 126 g/L will be recruited and followed prospectively for 18 months. Every six months after baseline, participants will have blood drawn to measure changes in hemoglobin and serum ferritin; LNG IUS users’ changes will be compared to OC-users. C-reactive protein, acid glycoprotein, and other parameters will be measured to fully isolate and explain possible reductions in anemia and rises in serum ferritin. Data on self-perceived changes in menstruation levels, satisfaction with the contraceptives, and dietary/supplement will be recorded.