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Non-Hodgkin Lymphoma (NHL) Subtypes Defined by Common Translocations: Utility of Fluorescence in Situ Hybridization (FISH) in a Case-Control Study

Citation

Chang, Cindy M.; Schroeder, Jane C.; Huang, Wen-Yi; Dunphy, Cherie H.; Baric, Ralph S.; Olshan, Andrew F.; Dorsey, Kathleen C.; Dent, Georgette A.; Cerhan, James R.; & Lynch, Charles F., et al. (2010). Non-Hodgkin Lymphoma (NHL) Subtypes Defined by Common Translocations: Utility of Fluorescence in Situ Hybridization (FISH) in a Case-Control Study. Leukemia Research, 34(2), 190-195. PMCID: PMC2815151

Abstract

We used fluorescence in situ hybridization (FISH) assays to identify t(14;18) translocations in archival paraffin-embedded tumor sections from non-Hodgkin lymphoma (NHL) cases enrolled in a population-based study. t(14;18) was identified in 54% of 152 cases, including 39% of diffuse large cell lymphomas (26 of 66 cases) and 84% of follicular lymphomas (36 of 43 cases). Eighty-seven percent of t(14;18)-positive cases and 57% of t(14;18)-negative cases expressed bcl-2. FISH assays detected twice as many t(14;18)-positive follicular lymphomas as PCR assays. Overall, study findings support the use of FISH assays to detect t(14;18) in archival tumor samples for epidemiologic studies of NHL subtypes.

URL

http://dx.doi.org/10.1016/j.leukres.2009.05.007

Reference Type

Journal Article

Year Published

2010

Journal Title

Leukemia Research

Author(s)

Chang, Cindy M.
Schroeder, Jane C.
Huang, Wen-Yi
Dunphy, Cherie H.
Baric, Ralph S.
Olshan, Andrew F.
Dorsey, Kathleen C.
Dent, Georgette A.
Cerhan, James R.
Lynch, Charles F.
Rothman, Nathaniel
Cantor, Kenneth P.
Blair, Aaron

PMCID

PMC2815151