Non-Hodgkin Lymphoma (NHL) Subtypes Defined by Common Translocations: Utility of Fluorescence in Situ Hybridization (FISH) in a Case-Control Study

Citation

Chang, Cindy M.; Schroeder, Jane C.; Huang, Wen-Yi; Dunphy, Cherie H.; Baric, Ralph S.; Olshan, Andrew F.; Dorsey, Kathleen C.; Dent, Georgette A.; Cerhan, James R.; & Lynch, Charles F., et al. (2010). Non-Hodgkin Lymphoma (NHL) Subtypes Defined by Common Translocations: Utility of Fluorescence in Situ Hybridization (FISH) in a Case-Control Study. Leukemia Research, 34(2), 190-195. PMCID: PMC2815151

Abstract

We used fluorescence in situ hybridization (FISH) assays to identify t(14;18) translocations in archival paraffin-embedded tumor sections from non-Hodgkin lymphoma (NHL) cases enrolled in a population-based study. t(14;18) was identified in 54% of 152 cases, including 39% of diffuse large cell lymphomas (26 of 66 cases) and 84% of follicular lymphomas (36 of 43 cases). Eighty-seven percent of t(14;18)-positive cases and 57% of t(14;18)-negative cases expressed bcl-2. FISH assays detected twice as many t(14;18)-positive follicular lymphomas as PCR assays. Overall, study findings support the use of FISH assays to detect t(14;18) in archival tumor samples for epidemiologic studies of NHL subtypes.

URL

http://dx.doi.org/10.1016/j.leukres.2009.05.007

Reference Type

Journal Article

Year Published

2010

Journal Title

Leukemia Research

Author(s)

Chang, Cindy M.
Schroeder, Jane C.
Huang, Wen-Yi
Dunphy, Cherie H.
Baric, Ralph S.
Olshan, Andrew F.
Dorsey, Kathleen C.
Dent, Georgette A.
Cerhan, James R.
Lynch, Charles F.
Rothman, Nathaniel
Cantor, Kenneth P.
Blair, Aaron

PMCID

PMC2815151

ORCiD

Olshan - 0000-0001-9115-5128