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The overall goals of this project are to investigate the influence of life course psychosocial stressors on DNA methylation and gene expression that may influence cardiometabolic health and depression in a US representative study of young adults. The findings from this study will have significant and lasting public health implications because our proposed testing of DNA methylation will be carried out in the largest sample of young adults in the US and made available to the global scientific community. The proposed research will inform our understanding of life course stress-related epigenetic and expression pathways, with potential for use in future prevention, diagnosis, and treatment of cardiometabolic conditions and depression.

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