Transition to a Western diet and cardiometabolic risk: Biomarkers derived from the microbiome
Summary
China is a rapidly modernizing country experiencing substantial transition from traditional to Westernized diet at different points in time, and across diverse geographic regions, along with increasing burden of obesity, diabetes and inflammation, providing a unique model for examining development of risk. This project investigates how long-term and short-term changes in diet, gut microbiota, gut microbiota-related plasma metabolites and microbiota-influenced markers of cardiometabolic disease interrelate in order to inform efforts to mitigate early development of disease risk across the globe.